Application of Oxyma Based Reagents in Relevant Organic Transformations

Show simple item record Kalita, Tapasi 2022-08-12T13:08:18Z 2022-08-12T13:08:18Z 2022
dc.identifier.other ROLL NO.146122038
dc.description Supervisor: Bhubaneswar Mandal en_US
dc.description.abstract The work presented in this thesis is mainly focused on the different applications of the coupling reagent ortho-NosylOXY (I) to synthesize acetals, thioacetals, ureas, carbamates, and thiocarbamates. A newer methodology is also described to convert carboxylic acids into amides, dipeptides, esters, and hydroxamates. In chapter 1, the importance of the compounds mentioned above, their existing methodologies, and their drawbacks are discussed. Chapter 2 describes the synthesis of acetals and thioacetals from aldehydes using ortho-NosylOXY . In chapter 3, the racemization-free synthesis of ureas, carbamates, and thiocarbamates from carboxylic acids via Curtius rearrangement using o-NosylOXY is demonstrated. The mechanism study of the Beckmann rearrangement from ketoxime to amide using o-NosylOXY is extended in chapter 4. Finally, in chapter 5, a one-pot protocol to synthesize amides, peptides, esters, and hydroxamates using Oxyma and thionyl chloride with minimal racemization is proposed. en_US
dc.language.iso en en_US
dc.relation.ispartofseries TH-2692;
dc.subject CHEMISTRY en_US
dc.title Application of Oxyma Based Reagents in Relevant Organic Transformations en_US
dc.type Thesis en_US

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