C-C and C-O Bond Formation through Umpolung Reactivity of Imine and Synthesis of Amide and Lactam using Meldrum’s Acid

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dc.contributor.author Ghosh, Santanu
dc.date.accessioned 2022-06-10T11:02:42Z
dc.date.available 2022-06-10T11:02:42Z
dc.date.issued 2021
dc.identifier.other ROLL NO.146122013
dc.identifier.uri http://gyan.iitg.ac.in/handle/123456789/2053
dc.description Supervisor: Chandan K Jana en_US
dc.description.abstract The contents of the thesis entitled “C-C and C-O bond formation through umpolung reactivity of imine and synthesis of amide and lactam using Meldrum’s acid” have been divided into 8 chapters based on the results of experimental works performed during the complete course of the research period. C-C and C-O bonds are abundant in most organic molecules. Therefore development of new methods for C-O and C-C bond formations is an important aspect of organic synthesis. Chapter 1 of the thesis presents a review on different aspects of umpolung reactivity of imine. Chapters 2-4 describe the studies on C-O and C-C bond formation using umpolung reactivity of imine. Chapter 2 describes a metal and oxidant free route to direct oxygenation of aldehyde to amide. In Chapter 3, metal free direct α-CH2-oxygenation of free amines has been described. The method was found to be efficient for the synthesis of important drugs and their anlogs. Dehydrogenative direct C-C coupling of unprotected primary amines with active methylenes has been described in Chapter 4. In Chapters 5-7 described the amides and lactams synthesis by using Meldrum’s acid. Three component coupling of arylaldehyde, amines, and Meldrum’s acid towards the synthesis of cinnamamides and piper amides has been described in Chapter 5. Chapter 6 describes decarboxylative N-, O-, and S-acetylation and acylation by using Meldrum’s acid. Diasteroselective ene-lactam synthesis via one pot sequential reactions has been described in Chapter 7. Finally, Chapter 8 contains the copies of 1H and 13C NMR spectra of selected new compounds. en_US
dc.language.iso en en_US
dc.relation.ispartofseries TH-2601;
dc.subject CHEMISTRY en_US
dc.title C-C and C-O Bond Formation through Umpolung Reactivity of Imine and Synthesis of Amide and Lactam using Meldrum’s Acid en_US
dc.type Thesis en_US


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